Chemical communications (Cambridge, England), 2015-05, Vol.51 (36), p.7626-7628
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids
- Ist Teil von
- Chemical communications (Cambridge, England), 2015-05, Vol.51 (36), p.7626-7628
- Ort / Verlag
- England: Royal Society of Chemistry
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine-eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1359-7345eISSN: 1364-548XDOI: 10.1039/c5cc01309gTitel-ID: cdi_hal_primary_oai_HAL_hal_03119331v1
- Format
- –
- Schlagworte
- Alkaloids, Aspidosperma - chemistry, Aspidosperma - metabolism, Backbone, Biocatalysis, Biosynthesis, Cytochrome P-450 Enzyme System - metabolism, Cytochromes P450, Enzymes, Formations, Life Sciences, Links, Molecular Conformation, Natural products, Vinblastine - analogs & derivatives, Vinblastine - biosynthesis, Vinblastine - chemistry, Vinca Alkaloids - chemistry, Vinca Alkaloids - metabolism