Details

Autor(en) / Beteiligte

• GRASSET, Fabien
• MORNET, Stéphane
• DEMOURGUES, Alain
• PORTIER, Josik
• BONNET, Jacques
• VEKRIS, Antoine
• DUGUET, Etienne

Titel

Synthesis, magnetic properties, surface modification and cytotoxicity evaluation of Y3Fe5-xAlxO12 (0≤x≤2) garnet submicron particles for biomedical applications

Ist Teil von

• Journal of magnetism and magnetic materials, 2001-09, Vol.234 (3), p.409-418

Ort / Verlag

Amsterdam: Elsevier Science

Erscheinungsjahr

2001

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Yttrium aluminum iron garnet Y3Fe5−xAlxO12 compounds were produced by the citrate gel process by varying the aluminum content x from 0 to 2. Particles with an average size of about 100 nm and a specific surface area ranging from 6 to 28 m2/g were obtained. Curie temperatures (TC) were determined from the temperature dependence of the field-cooled magnetization (FCM) and the remnant magnetization (REM) and range from –40°C to 280°C. According to the magnetic moment variation, the aluminum cation seems to replace the iron cation in the tetrahedral site for compounds with x<0.7. 3-Aminopropyltrimethoxysilane (γ-APS) was grafted onto the particles surface and its presence confirmed by infra-red spectroscopy. Cytotoxicity assays were carried out during a period of 13 days using human microglia and rat glioblastoma cell lines. The presence of the amine-functionalized particles did not affect the cell viability or the culture growth rate. Finally, amine-functionalized particles were successfully labeled with covalently linked fluorescing molecules.