UNIVERSI
TÄ
TS-
BIBLIOTHEK
P
ADERBORN
Anmelden
Menü
Menü
Start
Hilfe
Blog
Weitere Dienste
Neuerwerbungslisten
Fachsystematik Bücher
Erwerbungsvorschlag
Bestellung aus dem Magazin
Fernleihe
Einstellungen
Sprache
Deutsch
Deutsch
Englisch
Farbschema
Hell
Dunkel
Automatisch
Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist
gegebenenfalls
nur via VPN oder Shibboleth (DFN-AAI) möglich.
mehr Informationen...
Universitätsbibliothek
Katalog
Suche
Details
Zur Ergebnisliste
Ergebnis 10 von 1096
Datensatz exportieren als...
BibTeX
In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications
Contrast media and molecular imaging, 2008-03, Vol.3 (2), p.78-85
de Sousa, Paulo Loureiro
Livramento, João Bruno
Helm, Lothar
Merbach, André E.
Même, William
Doan, Bich-Thuy
Beloeil, Jean-Claude
Prata, Maria I. M.
Santos, Ana C.
C. Geraldes, Carlos F. G.
Tóth, Éva
2008
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
de Sousa, Paulo Loureiro
Livramento, João Bruno
Helm, Lothar
Merbach, André E.
Même, William
Doan, Bich-Thuy
Beloeil, Jean-Claude
Prata, Maria I. M.
Santos, Ana C.
C. Geraldes, Carlos F. G.
Tóth, Éva
Titel
In vivo MRI assessment of a novel GdIII-based contrast agent designed for high magnetic field applications
Ist Teil von
Contrast media and molecular imaging, 2008-03, Vol.3 (2), p.78-85
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2008
Quelle
MEDLINE
Beschreibungen/Notizen
Gd3L is a trinuclear Gd3+ complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H12L is based on a trimethylbenzene core bearing three methylene‐diethylenetriamine‐ N,N,N″,N″‐tetraacetate moieties). Thanks to its appropriate size, the presence of two inner sphere water molecules and a fast water exchange, Gd3L has remarkable proton relaxivities at high magnetic field (r1 = 10.2 vs 3.0 mM−1 s−1 for GdDOTA at 9.4 T, 37°C, in H2O). Here we report an in vivo MRI feasibility study, complemented with dynamic γ scintigraphic imaging and biodistribution experiments using the 153Sm‐enriched analog. MRI experiments were performed at 9.4 T in mice with Gd3L and the commercial contrast agent gadolinium(III)‐1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetate (GdDOTA). Gd3L was well tolerated by the animals at the dose of 8 µmol Gd kg−1 body weight. Dynamic contrast enhanced (DCE) images showed considerably higher signal enhancement in the kidney medulla and cortex after Gd3L injection than after GdDOTA injection at an identical dose. The relaxation rates, ΔR1, were calculated from the IR TrueFISP data. During the excretory phase, the ΔR1 for various tissues was similar for Gd3L and GdDOTA, when the latter was injected at a three‐fold higher dose (24 vs 8 µmol Gd kg−1 body weight). These results point to an approximately three times higher in vivo relaxivity (per Gd) for Gd3L relative to GdDOTA, thus the ratio of the relaxivities of the two compounds determined in vitro is retained under in vivo conditions. They also indicate that the two inner sphere water molecules per Gd in Gd3L are not substantially replaced by endogenous anions or other donor groups under physiological conditions. Gd3L has a pharmacokinetics typical of small, hydrophilic complexes, involving fast renal clearance and no retention in the blood pool. The dynamic γ scintigraphic studies and the biodistribution experiments performed in Wistar rats with 153Sm‐enriched *Sm3L are also indicative of a fast elimination via the kidneys. Copyright © 2008 John Wiley & Sons, Ltd. Gd3L is a rigid, medium‐size complex endowed with remarkable high field relaxivity. We have performed a feasibility MRI animal study with Gd3L as contrast agent (9.4 T), complemented with dynamic γ scintigraphic imaging and biodistribution experiments using the 153Sm‐enriched compound. Dynamic Contrast Enhanced images showed considerably higher signal enhancement in the kidney medulla and cortex after Gd3L than after GdDOTA injection at identical dose. Gd3L has a pharmacokinetics typical of small, hydrophilic complexes, involving fast renal clearance and no retention in the blood pool.
Sprache
Englisch
Identifikatoren
ISSN: 1555-4309
eISSN: 1555-4317
DOI: 10.1002/cmmi.233
Titel-ID: cdi_hal_primary_oai_HAL_hal_03059411v1
Format
–
Schlagworte
Animals
,
biodistribution
,
Bioengineering
,
Brain
,
Brain - anatomy & histology
,
Brain - metabolism
,
contrast agents
,
Gadolinium
,
Gadolinium - pharmacokinetics
,
high magnetic field
,
Image Enhancement
,
Image Enhancement - methods
,
Imaging
,
in vivo
,
Kidney
,
Kidney - anatomy & histology
,
Kidney - metabolism
,
Life Sciences
,
Magnetic Resonance Imaging
,
Magnetic Resonance Imaging - methods
,
Male
,
Metabolic Clearance Rate
,
Mice
,
Organ Specificity
,
pharmacokinetics
,
Tissue Distribution
,
Whole Body Imaging
,
Whole Body Imaging - methods
,
γ imaging
Weiterführende Literatur
Empfehlungen zum selben Thema automatisch vorgeschlagen von
bX