Nature cell biology, 1999-11, Vol.1 (7), p.404-408
1999
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- Autor(en) / Beteiligte
- Titel
- Calponin modulates the exclusion of Otx -expressing cells from convergence extension movements
- Ist Teil von
- Nature cell biology, 1999-11, Vol.1 (7), p.404-408
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 1999
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Otx2, a vertebrate homologue of the Drosophila orthodenticle gene, coordinates two processes in early embryonic development. Not only does it specify cell fate in the anterior regions of the embryo, it also prevents the cells that express it from participating in the convergence extension movements that shape the rest of the body axis. Here we show that, in Xenopus, this latter function is mediated by XclpH3, transcription of which is directly stimulated by Xotx2. XclpH3 is a Xenopus homologue of the mammalian calponin gene, the product of which binds both actin and myosin and prevents the generation of contractile force by actin filaments.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1465-7392, 1476-4679eISSN: 1476-4679DOI: 10.1038/15635Titel-ID: cdi_hal_primary_oai_HAL_hal_03043914v1
- Format
- –
- Schlagworte
- actin, Animals, Biomechanics, Blotting, Western, Body Patterning - genetics, Body Patterning - physiology, Calcium-Binding Proteins - metabolism, calponin, Calponins, Cloning, Molecular, Cycloheximide - pharmacology, Development Biology, Dexamethasone - pharmacology, Drosophila, Embryo, Nonmammalian - metabolism, Embryonic Development, Glucocorticoids - pharmacology, Homeodomain Proteins, In Situ Hybridization, Life Sciences, Mechanics, Microfilament Proteins - metabolism, Microinjections, Molecular Sequence Data, Morphogenesis, Nerve Tissue Proteins - genetics, Nerve Tissue Proteins - metabolism, Otx gene, Otx Transcription Factors, Phenotype, Physics, Protein Processing, Post-Translational, Protein Synthesis Inhibitors - pharmacology, Recombinant Fusion Proteins - genetics, Recombinant Fusion Proteins - metabolism, RNA - metabolism, Trans-Activators - genetics, Trans-Activators - metabolism, XclpH3 gene, Xenopus, Xenopus - embryology, Xenopus Proteins, Xotx2 gene