Details

Autor(en) / Beteiligte

• Guedj, Carole
• Monfardini, Elisabetta
• Reynaud, Amélie J
• Farnè, Alessandro
• Meunier, Martine
• Hadj-Bouziane, Fadila

Titel

Boosting Norepinephrine Transmission Triggers Flexible Reconfiguration of Brain Networks at Rest

Ist Teil von

• Cerebral cortex (New York, N.Y. 1991), 2017-10, Vol.27 (10), p.4691-4700

Ort / Verlag

United States: Oxford University Press (OUP)

Erscheinungsjahr

2017

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The locus coeruleus-norepinephrine (LC-NE) system is thought to act as a reset signal allowing brain network reorganization in response to salient information in the environment. However, no direct evidence of NE-dependent whole-brain reorganization has ever been described. We used resting-state functional magnetic resonance imaging in monkeys to investigate the impact of NE-reuptake inhibition on whole-brain connectivity patterns. We found that boosting NE transmission changes functional connectivity between and within resting-state networks. It modulated the functional connectivity pattern of a brainstem network including the LC region and interactions between associative and sensory-motor networks as well as within sensory-motor networks. Among the observed changes, those involving the fronto-parietal attention network exhibited a unique pattern of uncoupling with other sensory-motor networks and correlation switching from negative to positive with the brainstem network that included the LC nucleus. These findings provide the first empirical evidence of NE-dependent large-scale brain network reorganization and further demonstrate that the fronto-parietal attention network represents a central feature within this reorganization.