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Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb
Journal of comparative neurology (1911), 2010-06, Vol.518 (11), p.1976-1994
Lepousez, Gabriel
Csaba, Zsolt
Bernard, Véronique
Loudes, Catherine
Videau, Catherine
Lacombe, Joelle
Epelbaum, Jacques
Viollet, Cécile
2010
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Lepousez, Gabriel
Csaba, Zsolt
Bernard, Véronique
Loudes, Catherine
Videau, Catherine
Lacombe, Joelle
Epelbaum, Jacques
Viollet, Cécile
Titel
Somatostatin interneurons delineate the inner part of the external plexiform layer in the mouse main olfactory bulb
Ist Teil von
Journal of comparative neurology (1911), 2010-06, Vol.518 (11), p.1976-1994
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2010
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Neuropeptides play a major role in the modulation of information processing in neural networks. Somatostatin, one of the most concentrated neuropeptides in the brain, is found in many sensory systems including the olfactory pathway. However, its cellular distribution in the mouse main olfactory bulb (MOB) is yet to be characterized. Here we show that ≈95% of mouse bulbar somatostatin‐immunoreactive (SRIF‐ir) cells describe a homogeneous population of interneurons. These are restricted to the inner lamina of the external plexiform layer (iEPL) with dendritic field strictly confined to the region. iEPL SRIF‐ir neurons share some morphological features of Van Gehuchten short‐axon cells, and always express glutamic acid decarboxylase, calretinin, and vasoactive intestinal peptide. One‐half of SRIF‐ir neurons are parvalbumin‐ir, revealing an atypical neurochemical profile when compared to SRIF‐ir interneurons of other forebrain regions such as cortex or hippocampus. Somatostatin is also present in fibers and in a few sparse presumptive deep short‐axon cells in the granule cell layer (GCL), which were previously reported in other mammalian species. The spatial distribution of somatostatin interneurons in the MOB iEPL clearly outlines the region where lateral dendrites of mitral cells interact with GCL inhibitory interneurons through dendrodendritic reciprocal synapses. Symmetrical and asymmetrical synaptic contacts occur between SRIF‐ir dendrites and mitral cell dendrites. Such restricted localization of somatostatin interneurons and connectivity in the bulbar synaptic network strongly suggest that the peptide plays a functional role in the modulation of olfactory processing. J. Comp. Neurol. 518:1976–1994, 2010. © 2010 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0021-9967
eISSN: 1096-9861
DOI: 10.1002/cne.22317
Titel-ID: cdi_hal_primary_oai_HAL_hal_03013523v1
Format
–
Schlagworte
Animals
,
Biomarkers
,
Biomarkers - metabolism
,
Calbindin 2
,
EPL
,
GABA
,
Humans
,
Immunohistochemistry
,
Interneurons
,
Interneurons - cytology
,
Interneurons - metabolism
,
Life Sciences
,
Male
,
Mice
,
Mice, Knockout
,
Neurons and Cognition
,
neuropeptide
,
Olfactory Bulb
,
Olfactory Bulb - anatomy & histology
,
reciprocal synapse
,
S100 Calcium Binding Protein G
,
S100 Calcium Binding Protein G - metabolism
,
Somatostatin
,
Somatostatin - metabolism
,
SRIF
,
Synapses
,
Synapses - metabolism
,
Synapses - ultrastructure
,
Van Gehuchten
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