Details

Autor(en) / Beteiligte

• Joueidi, Y.
• Peoc’h, K.
• Le Lous, M.
• Bouzille, G.
• Rousseau, C.
• Bardou-Jacquet, E.
• Bendavid, C.
• Damaj, L.
• Fromenty, B.
• Lavoué, V.
• Moreau, C.

Titel

Maternal and neonatal outcomes and prognostic factors in acute fatty liver of pregnancy

Ist Teil von

• European Journal of Obstetrics & Gynecology and Reproductive Biology, 2020-09, Vol.252, p.198-205

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2020

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• •We analyzed acute fatty liver of pregnancy in a large multicenter cohort.•Incidence of AFLP was estimated as one case for 7914 pregnancies.•Increased prothrombin time is a risk factor of maternal complications.•Infants born to mothers with ALFP should be screened for β-oxidation deficiency. To report complications of Acute Fatty Liver of pregnancy (AFLP), a rare liver disease of pregnancy, and identify prognostic factors for mothers and children. We conducted a retrospective descriptive study over 18 years in three French maternities. Demographic, clinical, biological data, and outcomes of patients and their infants were reviewed. 142,450 pregnancies from centers were studied. Eighteen patients with AFLP were identified The prevalence of AFLP was estimated as 1/7,914 pregnancies. Prolonged prothrombin time was identified as a risk factor of maternal complications (OR = 0.86, p = 0.0493). Gestational age at delivery was the only risk factor associated with fetal or neonate complications (OR = 0.37, p = 0.0417). One boy died of previously undiagnosed β-oxidation deficiency at eight months. In AFLP, prothrombin time must be carefully monitored to anticipate major maternal complications. Infants born to mothers with ALFP should be screened as early as possible for mitochondrial fatty acid oxidation deficiency.