Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Structure and Variations of Feline Immunodeficiency Virus Envelope Glycoproteins
Ist Teil von
Virology (New York, N.Y.), 1993-02, Vol.192 (2), p.659-662
Ort / Verlag
San Diego, CA: Elsevier Inc
Erscheinungsjahr
1993
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
We report the characterization of the
env gene of a feline immunodeficiency virus isolate from France (FIV Wo). FIV Wo
gag and
env genes were cloned directly from cat peripheral blood mononuclear cells, using polymerase chain reaction. The
env molecular clone was shown to be functional and to express antigenically relevant envelope glycoproteins
in vitro. Alignment of FIV Wo sequences with available FIV sequences and application of a regionalization algorithm resulted in delineation of variable and conserved domains of FIV Env. These data were used to build a schematic folding model of FIV envelope glycoproteins. The Env molecular clone, variability map, and structural model constitute helpful tools for future studies of FIV envelope aimed at the determination of structure-function relationships or design of diagnostics or vaccine reagents.