Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Control of glucose metabolism in newborn pig enterocytes: Evidence for the role of hexokinase
Ist Teil von
Biochimica et biophysica acta, 1994-11, Vol.1224 (2), p.213-220
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
1994
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
The objective of the present work was to identify the regulatory step(s) in the post-natal development of a high glycolytic capacity previously evidenced in newborn pig enterocytes (Darcy-Vrillon et al. (1994) Pediat. Res., 36, 175–181. Glucose entry via the
Na
+
glucose
cotransporter, estimated by the uptake of the non-metabolizable analogue methyl α-
d-[U-
14C]glucopyranoside, slightly decreased between birth and 2 days of sucking. The flux of glucose metabolized into the pentose cycle pathway slightly increased but could not account for the 3-fold increase observed in the glycolytic capacity. Whereas the maximal activity of 6-phosphofructo-1-kinase did not change between stages, there was a significant increase in hexokinase activity as well as in the flux of glucose phosphorylated. These findings suggest that the stimulation of glucose phosphorylation through hexokinase is the key event leading to an increased glycolytic capacity of small intestinal cells at the onset of sucking.