Details

Autor(en) / Beteiligte

• Chechetka, Svetlana A.
• Yuba, Eiji
• Kono, Kenji
• Yudasaka, Masako
• Bianco, Alberto
• Miyako, Eijiro

Titel

Magnetically and Near-Infrared Light-Powered Supramolecular Nanotransporters for the Remote Control of Enzymatic Reactions

Ist Teil von

• Angewandte Chemie International Edition, 2016-05, Vol.55 (22), p.6476-6481

Auflage

International ed. in English

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Cancer is one of the primary causes of death worldwide. A high‐precision analysis of biomolecular behaviors in cancer cells at the single‐cell level and more effective cancer therapies are urgently required. Here, we describe the development of a magnetically‐ and near infrared light‐triggered optical control method, based on nanorobotics, for the analyses of cellular functions. A new type of nanotransporters, composed of magnetic iron nanoparticles, carbon nanohorns, and liposomes, was synthesized for the spatiotemporal control of cellular functions in cells and mice. Our technology will help to create a new state‐of‐the‐art tool for the comprehensive analysis of “real” biological molecular information at the single‐cell level, and it may also help in the development of innovative cancer therapies. Nanorobots: Magnetic nanoparticle–carbon nanohorn–liposome supramolecular nanotransporters were developed. The remotely controlled release of functional molecules contained in the nanotransporters was achieved by applying a magnetic field and near‐infrared laser light. The nanotransporters enabled enzymatic reactions at target sites in cells and mice.