Details

Autor(en) / Beteiligte

• Ouvry, Gilles
• Bihl, Franck
• Bouix-Peter, Claire
• Christin, Olivier
• Defoin-Platel, Claire
• Deret, Sophie
• Feret, Christophe
• Froude, David
• Hacini-Rachinel, Feriel
• Harris, Craig S.
• Hervouet, Catherine
• Lafitte, Guillaume
• Luzy, Anne-Pascale
• Musicki, Branislav
• Orfila, Danielle
• Parnet, Veronique
• Pascau, Coralie
• Pascau, Jonathan
• Pierre, Romain
• Raffin, Catherine
• Rossio, Patricia
• Spiesse, Delphine
• Taquet, Nathalie
• Thoreau, Etienne
• Vatinel, Rodolphe
• Vial, Emmanuel
• Hennequin, Laurent F.

Titel

Sulfoximines as potent RORγ inverse agonists

Ist Teil von

• Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1269-1273

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Compound 4a CD4 IL-17 IC50 = 17 nM. [Display omitted] Progress in the identification of suitable RORγ inverse agonists as clinical candidates has been hampered by the high lipophilicity that seems required for high potency on this nuclear receptor. In this context, we decided to focus on the replacement of the hydroxymethyl group found on known modulators to determine if more polarity could be tolerated in this position. SAR of the replacement of this moiety is presented in this article leading to the identification of sulfoximine derivatives as potent modulators with pharmacological activity in the in vivo mouse Imiquimod psoriasis model.