Details

Autor(en) / Beteiligte

• Aragon, Pierre-Jean
• Yapi, Ange-Désiré
• Pinguet, Frédéric
• Chezal, Jean-Michel
• Teulade, Jean-Claude
• Blache, Yves

Titel

Synthesis and Biological Evaluation of Indoloquinolines and Pyridocarbazoles: A New Example of Unexpected Photoreduction Accompanying Photocyclization

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 2007/09/01, Vol.55(9), pp.1349-1355

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• Indoloquinoline alkaloid cryptolepine and pyridocarbazole alkaloid ellipticine are of great interest because in vitro and in vivo studies revealed their good cytotoxic properties. In order to obtain some biologically active analogs of these compounds, we developed a synthesis based on the photocyclization of tertiary N-substituted enaminones derived from 1,3-cyclohexandione and 3 or 6-aminoquinoline. The angular cyclized compounds thus obtained were tested in vitro on K 562 cells and A 2780 doxorubicin sensitive and resistant cells. All compounds were less effective than doxorubicin in sensitive cells but their activity wasn't decreased by MDR resistance.