Details

Autor(en) / Beteiligte

• Arya, P.
• Quevillon, S.
• Joseph, R.
• Wei, C.-Q.
• Gan, Z.
• Parisien, M.
• Sesmilo, E.
• Reddy, P. T.
• Chen, Z.-X
• Durieux, P.
• Laforce, D.
• Campeau, L.-C.
• Khadem, S.
• Couve-Bonnaire, S.
• Kumar, R.
• Sharma, U.
• Leek, D. M.
• Daroszewska, M.
• Barnes, M. L.

Titel

Toward the library generation of natural product-like polycyclic derivatives by stereocontrolled diversity-oriented synthesis

Ist Teil von

• Pure and applied chemistry, 2005-01, Vol.77 (1), p.163-178

Ort / Verlag

Berlin: De Gruyter

Erscheinungsjahr

2005

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Due to the growing interest in small molecules that could help in understanding protein–protein interactions based on signal transduction, the demand for the generation of small-molecule libraries that are inspired by bioactive natural products has grown significantly. Many of these pathways are highly complex and present tremendous challenges with the use of classical tools. A rapid access to natural product-like small molecules having structural complexity and diversity is crucial for systematically dissecting the functions of complex protein networking and understanding cell signaling pathways. The complex nature, the three-dimensional architecture, and the number of protein binding functional groups presented in three-dimensional arrays are some of the attractive features to incorporate in small-molecule chemical probes to be used as modulators of protein function.