Details

Autor(en) / Beteiligte

• Brossette, Thierry
• Klein, Emmanuel
• Créminon, Christophe
• Grassi, Jacques
• Mioskowski, Charles
• Lebeau, Luc

Titel

Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides

Ist Teil von

• Tetrahedron, 2001-09, Vol.57 (38), p.8129-8143

Ort / Verlag

Elsevier Ltd

Erscheinungsjahr

2001

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• A series of nine modified dideoxynucleosides and dideoxynucleotides has been synthesized for preparing antigenic conjugates with keyhole lympet haemocyanin in order to produce specific antibodies, and develop immunoassays. Derivatives of ddI, ddA, d4T, 3TC, and the corresponding 5′- O-monophosphates were designed incorporating an amino spacer at the base for conjugation with the proteinic antigenic carrier. ddI, ddA, d4T, and 3TC derived haptens and the corresponding mono-phosphates have been synthesized for specific antibody production.