Details

Autor(en) / Beteiligte

• Janela, Baptiste
• Patel, Amit A.
• Lau, Mai Chan
• Goh, Chi Ching
• Msallam, Rasha
• Kong, Wan Ting
• Fehlings, Michael
• Hubert, Sandra
• Lum, Josephine
• Simoni, Yannick
• Malleret, Benoit
• Zolezzi, Francesca
• Chen, Jinmiao
• Poidinger, Michael
• Satpathy, Ansuman T.
• Briseno, Carlos
• Wohn, Christian
• Malissen, Bernard
• Murphy, Kenneth M.
• Maini, Alexander A.
• Vanhoutte, Leen
• Guilliams, Martin
• Vial, Emmanuel
• Hennequin, Laurent
• Newell, Evan
• Ng, Lai Guan
• Musette, Philippe
• Yona, Simon
• Hacini-Rachinel, Feriel
• Ginhoux, Florent

Titel

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Ist Teil von

• Immunity (Cambridge, Mass.), 2019-04, Vol.50 (4), p.1069-1083.e8

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• Skin conventional dendritic cells (cDCs) exist as two distinct subsets, cDC1s and cDC2s, which maintain the balance of immunity to pathogens and tolerance to self and microbiota. Here, we examined the roles of dermal cDC1s and cDC2s during bacterial infection, notably Propionibacterium acnes (P. acnes). cDC1s, but not cDC2s, regulated the magnitude of the immune response to P. acnes in the murine dermis by controlling neutrophil recruitment to the inflamed site and survival and function therein. Single-cell mRNA sequencing revealed that this regulation relied on secretion of the cytokine vascular endothelial growth factor α (VEGF-α) by a minor subset of activated EpCAM+CD59+Ly-6D+ cDC1s. Neutrophil recruitment by dermal cDC1s was also observed during S. aureus, bacillus Calmette-Guérin (BCG), or E. coli infection, as well as in a model of bacterial insult in human skin. Thus, skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation. [Display omitted] •cDC1s regulate the magnitude of the innate immune response to cutaneous bacteria•cDC1s control neutrophil recruitment, survival, and functions in inflamed skin•Activated EpCAM+CD59+Ly-6D+ cDC1s control neutrophil biology via VEGF-α secretion•cDC1s secrete VEGF-α in a model of bacterial insult in human skin Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.