Leukemia research, 2007-05, Vol.31 (5), p.629-638
2007
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- Autor(en) / Beteiligte
- Titel
- Endostatin variations in childhood acute lymphoblastic leukaemia—Comparison with basic fibroblast growth factor and vascular endothelial growth factor
- Ist Teil von
- Leukemia research, 2007-05, Vol.31 (5), p.629-638
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2007
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Angiogenic factors such as basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) were previously studied in childhood acute lymphoblastic leukaemia (ALL) but little is known concerning the anti-angiogenic response in ALL. At diagnosis, the plasma levels of the anti-angiogenic factor endostatin were significantly higher in 33 children with ALL than in controls (median values 17.7 and 7.6 ng/ml, respectively, p = 0.0192) but no relationship was observed with plasma bFGF or VEGF levels. The highest levels were observed in patients with an hyperdiploïd karyotype. Expression of mRNA for collagen XVIII/endostatin in lymphoblasts was detected in 19/24 cases but protein secretion was found only in 14/28 supernatants of cultured lymphoblasts. No direct relationship appeared between secretion of endostatin by lymphoblasts and plasma levels. In addition, endostatin levels remained elevated in remission, suggesting that endostatin could have a stromal origin as well. No prognostic value of plasma endostatin could be assessed. In conclusion, the present data indicate that an anti-angiogenic response is observed in some ALL children, but its physiopathological importance remains to be established.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0145-2126eISSN: 1873-5835DOI: 10.1016/j.leukres.2006.08.023Titel-ID: cdi_hal_primary_oai_HAL_hal_02340676v1
- Format
- –
- Schlagworte
- Acute lymphoblastic leukaemia, Adolescent, Angiogenesis, Blotting, Western, Case-Control Studies, Cell Proliferation, Child, Child, Preschool, Childhood, Endostatin, Endostatins, Endostatins - genetics, Endostatins - metabolism, Environmental Sciences, Enzyme-Linked Immunosorbent Assay, Fibroblast Growth Factor 2, Fibroblast Growth Factor 2 - genetics, Fibroblast Growth Factor 2 - metabolism, Hematology, Oncology and Palliative Medicine, Hepatomegaly, Humans, Immunoenzyme Techniques, Immunophenotyping, Infant, Life Sciences, Lymphocytes, Lymphocytes - metabolism, Microenvironment, Neoplasm Recurrence, Local, Neoplasm Recurrence, Local - genetics, Neoplasm Recurrence, Local - metabolism, Neoplasm Recurrence, Local - pathology, Neovascularization, Pathologic, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood, Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology, Precursor Cell Lymphoblastic Leukemia-Lymphoma - urine, Remission Induction, Reverse Transcriptase Polymerase Chain Reaction, RNA, Messenger, RNA, Messenger - genetics, RNA, Messenger - metabolism, RNA, Neoplasm, RNA, Neoplasm - genetics, RNA, Neoplasm - metabolism, Vascular Endothelial Growth Factor A, Vascular Endothelial Growth Factor A - genetics, Vascular Endothelial Growth Factor A - metabolism