Neuroscience, 2015-11, Vol.309, p.243-258
2015
Details
- Autor(en) / Beteiligte
- Titel
- Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis
- Ist Teil von
- Neuroscience, 2015-11, Vol.309, p.243-258
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Methylphenidate (MPH) has different effects in young vs. adult rats. • MPH impairs object recognition in adolescent rats, but not adults. • MPH induces depressive-like behavior in adult rats, but not adolescent rats. • MPH induces opposite effects on neurogenesis, and hippocampal shape. • These findings are highly relevant for patients treated with MPH for attention deficit hyperactivity disorder (ADHD).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2015.04.044Titel-ID: cdi_hal_primary_oai_HAL_hal_02193376v1
- Format
- –
- Schlagworte
- Administration, Oral, Aging - drug effects, Aging - pathology, Aging - physiology, Aging - psychology, Animals, Attention Deficit Disorder with Hyperactivity - drug therapy, Central Nervous System Stimulants - toxicity, Cognitive science, Depressive Disorder - chemically induced, Depressive Disorder - pathology, Depressive Disorder - physiopathology, depressive-like behavior, hippocampus, Hippocampus - drug effects, Hippocampus - growth & development, Hippocampus - pathology, Hippocampus - physiology, Humanities and Social Sciences, Immunohistochemistry, Life Sciences, Magnetic Resonance Imaging, Male, memory, methylphenidate, Methylphenidate - toxicity, MRI, Neural Pathways - drug effects, Neural Pathways - growth & development, Neural Pathways - pathology, Neural Pathways - physiopathology, neurogenesis, Neurogenesis - drug effects, Neurogenesis - physiology, Neurology, Neuroscience, Psychology, Rats, Wistar, Recognition (Psychology) - drug effects, Recognition (Psychology) - physiology, Rest