Details

Autor(en) / Beteiligte

• Saha, Manash
• Menuet, Clement
• Sun, Qi- Jian
• Burke, Peter G.R.
• Hildreth, Cara M.
• Allen, Andrew M.
• Phillips, Jacqueline K.

Titel

Respiratory sympathetic modulation is augmented in chronic kidney disease

Ist Teil von

• Respiratory physiology & neurobiology, 2019-04, Vol.262, p.57-66

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2019

Quelle

MEDLINE

Beschreibungen/Notizen

• •Interactions between CNS networks leads to a coupling of sympathetic nerve activity to the respiratory cycle.•In chronic kidney disease, this respiratory-sympathetic coupling may drive sympathoexcitation, and in turn hypertension.•In a rat model chronic kidney disease we show enhanced respiratory-sympathetic coupling in both young and adult animals.•We also demonstrate an exaggerated sympathoexcitatory response to stimulation of the peripheral chemoreceptors.•Respiratory-sympathetic coupling may be a potential target to reduce high blood pressure in chronic kidney disease. Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions (n = 8–10/strain), respiratory modulation of splanchnic and renal nerve activity was compared under control conditions, and during peripheral (hypoxia), and central, chemoreceptor (hypercapnia) challenge. RespSNA was increased in the LPK vs. Lewis (area under curve (AUC) splanchnic and renal: 8.7 ± 1.1 vs. 3.5 ± 0.5 and 10.6 ± 1.1 vs. 7.1 ± 0.2 μV.s, respectively, P < 0.05). Hypoxia and hypercapnia increased respSNA in both strains but the magnitude of the response was greater in LPK, particularly in response to hypoxia. In juvenile animals studied using a working heart brainstem preparation (n = 7–10/strain), increased respSNA was evident in the LPK (thoracic SNA, AUC: 0.86 ± 0.1 vs. 0.42 ± 0.1 μV.s, P < 0.05), and activation of peripheral chemoreceptors (NaCN) again drove a larger increase in respSNA in the LPK with no difference in the response to hypercapnia. Amplified respSNA occurs in CKD and may contribute to the development of hypertension.