Details

Autor(en) / Beteiligte

• Barral, Karine
• Moorhouse, Adam D
• Moses, John E

Titel

Efficient Conversion of Aromatic Amines into Azides:  A One-Pot Synthesis of Triazole Linkages

Ist Teil von

• Organic letters, 2007-04, Vol.9 (9), p.1809-1811

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2007

Quelle

MEDLINE

Beschreibungen/Notizen

• An efficient and improved procedure for the preparation of aromatic azides and their application in the Cu(I)-catalyzed azide−alkyne 1,3-dipolar cycloaddition (“click reaction”) is described. The synthesis of aromatic azides from the corresponding amines is accomplished under mild conditions with tert-butyl nitrite and azidotrimethylsilane. 1,4-Disubstituted 1,2,3-triazoles were obtained in excellent yields from a variety of aromatic amines without the need for isolation of the azide intermediates.