Details

Autor(en) / Beteiligte

• Popgeorgiev, Nikolay
• Colson, Philippe
• Thuret, Isabelle
• Chiarioni, Jacques
• Gallian, Pierre
• Raoult, Didier
• Desnues, Christelle

Titel

Marseillevirus prevalence in multitransfused patients suggests blood transmission

Ist Teil von

• Journal of clinical virology, 2013-12, Vol.58 (4), p.722-725

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Emerging viral infections in humans are appearing at an increasing rate. Recently, we identified a new Marseillevirus, named Giant Blood Marseillevirus (GBM), by performing viral metagenomics on asymptomatic blood donors. Objectives To study and compare the prevalence of Marseillevirus between asymptomatic blood donors and thalassemia patients. Design Here, we present a combined molecular and serological study on 174 asymptomatic blood donors and 22 patients with thalassemia who receive repeated blood transfusions to estimate the prevalence of Marseillevirus in these two populations. Results We identified Marseillevirus genomic DNA in 4% of donors, whereas 9.1% of the thalassemia patients were positive for this virus. Moreover, IgG seropositivity was detected in 22.7% of patients in the thalassemia group, whereas this seropositivity was observed in 12.6% of the blood donor population. Conclusion These results suggest that Marseillevirus infection is not rare in healthy persons and may be transmitted by transfusion, thus raising speculation regarding the long-term consequences of this viral infection, particularly in patients requiring repeated blood transfusions.