Details

Autor(en) / Beteiligte

• Pineton de Chambrun, Guillaume
• Dauchet, Luc
• Gower-Rousseau, Corinne
• Cortot, Antoine
• Colombel, Jean-Frédéric
• Peyrin-Biroulet, Laurent

Titel

Vaccination and Risk for Developing Inflammatory Bowel Disease: A Meta-Analysis of Case–Control and Cohort Studies

Ist Teil von

• Clinical gastroenterology and hepatology, 2015-08, Vol.13 (8), p.1405-1415.e1

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Background & Aims Environmental factors may play a key role in the pathogenesis of inflammatory bowel disease (IBD). Whether vaccination is associated causally with IBD is controversial. We performed a meta-analysis of case–control and cohort studies on the association between vaccination and the risk for IBD. Methods Studies and abstracts investigating the relationship between vaccination and subsequent risk for developing IBD were reviewed. Childhood or adult immunizations with any vaccine type, at any dose, and with any vaccine schedule were used as inclusion criteria. Results Eleven studies were included in the systematic review and meta-analysis: 8 case–control studies and 3 cohort studies. Studied vaccines were bacille Calmette–Guérin), vaccines against diphtheria, tetanus, smallpox, poliomyelitis, pertussis, H1N1, measles, rubella, mumps, and the combined measles, mumps, and rubella vaccine. Only a few details about vaccine type or route of administration were found in studies. Overall, there was no association between childhood immunization and risk for developing IBD: bacille Calmette–Guérin, relative risk (RR) of 1.04 (95% confidence interval [CI], 0.78–1.38), diphtheria, RR of 1.24 (95% CI, 0.80–1.94), tetanus, RR of 1.27 (95% CI, 0.77–2.08), smallpox, RR of 1.08 (95% CI, 0.70–1.67), poliomyelitis, RR of 1.79 (95% CI, 0.88–3.66), an measles containing vaccines, RR of 1.33 (95% CI, 0.31–5.80) in cohort studies, and RR of 0.85 (95% CI, 0.60–1.20) in case–control studies. Subgroup analysis for Crohn’s disease (CD) and ulcerative colitis (UC) found an association between the poliomyelitis vaccine and risk for developing CD (RR, 2.28; 95% CI, 1.12–4.63) or UC (RR, 3.48; 95% CI, 1.2–9.71). The RR of developing IBD after H1N1 vaccination was 1.13 (95% CI, 0.97–1.32). Conclusions Results of this meta-analysis show no evidence supporting an association between childhood immunization or H1N1 vaccination in adults and risk of developing IBD. The association between the poliomyelitis vaccine and the risk for CD or UC should be analyzed with caution because of study heterogeneity.