Details

Autor(en) / Beteiligte

• Zhang, Chen
• Bu, Wenbo
• Ni, Dalong
• Zhang, Shenjian
• Li, Qing
• Yao, Zhenwei
• Zhang, Jiawen
• Yao, Heliang
• Wang, Zheng
• Shi, Jianlin

Titel

Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Ist Teil von

• Angewandte Chemie International Edition, 2016-02, Vol.55 (6), p.2101-2106

Auflage

International ed. in English

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2O2 in a tumor microenvironment: Ionization of the AFeNPs enables on‐demand ferrous ion release in the tumor, and subsequent H2O2 disproportionation leads to efficient .OH generation. The endogenous stimuli‐responsive .OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input. Amorphous iron nanoparticles (AFeNPs) can be used for cancer theranostics. Ionization of the AFeNPs in the mildly acidic tumor microenvironment promotes the release of ferrous ions in the tumor; these induce H2O2 disproportionation, which in turn leads to efficient .OH generation and significant tumor growth inhibition.