Details

Autor(en) / Beteiligte

• Auzolle, Claire
• Nancey, Stephane
• Tran‐Minh, My‐Linh
• Buisson, Anthony
• Pariente, Benjamin
• Stefanescu, Carmen
• Fumery, Mathurin
• Marteau, Philippe
• Treton, Xavier
• Hammoudi, Nassim
• Jouven, Xavier
• Seksik, Philippe
• Allez, Matthieu
• Cattan, Pierre
• Chirica, Mirea
• Munoz‐Bongrand, Nicolas
• Corte, Hélène
• Gornet, Jean‐Marc
• Baudry, Clotilde
• Lourenco, Nelson
• Maillet, Mariane
• Le Bourhis, Lionel
• Chardiny, Victor
• Grand, Céline
• Djenidi, Faycal
• Nisard, Andrée
• Beaugerie, Laurent
• Sokol, Harry
• Bourrier, Anne
• Nion‐Larmurier, Isabelle
• Landman, Cecilia
• Rajca, Sylvie
• Quevrain, Elodie
• Brot, Loic
• Chafai, Najim
• Lefevre, Jeremie
• Tiret, Emmanuel
• Svreck, Magali
• Hoyau‐Idrissi, Nadia
• François Flejou, Jean
• Guedj, Nathalie
• Panis, Yves
• Magiorri, Leon
• Feron, Mariane
• Bouhnik, Yoram
• Corcos, Olivier
• Dray, Xavier
• Chaput, Ulrika
• Bommelaer, Gilles
• Goutte, Marion
• Barnich, Nicolas
• Desreumaux, Pierre
• Nachury, Maria
• Sommeville, Coralie
• Dupas, Jean‐Louis
• Brazier, Franck
• Chatelain, Denis
• Attencourt, Christophe
• Sabbagh, Charles
• Leconte, Martine
• Boschetti, Gilles
• Flourié, Bernard
• François, Yves
• Cotte, Eddy
• Charlois, Anne‐Laure
• Falgon, Peggy
• Moussata, Driffa
• Chauvenet, Marion
• Boyer, Sarah
• Hebuterne, Xavier
• Filippi, Jérome
• Hofmann, Paul
• Margalef, Carole
• Detre, Patricia
• Empana, Jean‐Philippe
• Perier, Marie‐Cécile

Titel

Male gender, active smoking and previous intestinal resection are risk factors for post‐operative endoscopic recurrence in Crohn's disease: results from a prospective cohort study

Ist Teil von

• Alimentary Pharmacology & Therapeutics (Suppl), 2018-11, Vol.48 (9), p.924-932

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Summary Background After ileocaecal resection for Crohn's disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo‐terminal ileum. Aim To identify predictors of early post‐operative endoscopic recurrence. Methods From September 2010 to September 2017, the REMIND group conducted a prospective nationwide study in nine French academic centres. Data were collected at the time of surgery and endoscopy, performed 6‐12 months after surgery. Endoscopic recurrence was defined as a Rutgeerts score ≥i2. Baseline factors associated with endoscopic recurrence were searched by univariate and multivariate regression analysis. Results Two hundred and eighty‐nine CD patients were included. Endoscopy within 1 year following surgery was performed in 225 (78%) patients (104M/121F). Mean age and disease duration were 35 (12.2) and 8.8 (8.9) years respectively. Seventy (32%) patients were active smokers at surgery. One hundred and forty‐two (63%) patients received at least one anti‐TNF therapy before surgery. After surgery, 40 (18%) patients received thiopurines and 66 (29%) received an anti‐TNF agent. Endoscopic recurrence occurred in 107 (47%) patients. In multivariate analysis, male gender (OR = 2.48 [IC 95% 1.40‐4.46]), active smoking at surgery (OR = 2.65 [IC 95% 1.44‐4.97]) and previous resection (OR = 3.03 [IC 95% 1.36‐7.12]) were associated with a higher risk of endoscopic recurrence. Inversely, post‐operative anti‐TNF treatment decreased the risk of endoscopic recurrence (OR = 0.50 [IC 95% 0.25‐0.96]). Conclusions Male gender, active smoking at surgery and previous intestinal resection are associated with a higher risk of endoscopic post‐operative recurrence, while post‐operative anti‐TNF treatment is associated with a lower risk. Linked Content This article is linked to Yamamoto and Kotze, and Imperatore et al papers. To view these articles visit https://doi.org/10.1111/apt.14985 and https://doi.org/10.1111/apt.14989.