Details

Autor(en) / Beteiligte

• Meyers, M
• Granger, B
• Herman, P
• Janot, F
• Garrel, R
• Fakhry, N
• Poissonnet, G
• Baujat, B

Titel

Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases

Ist Teil von

• European annals of otorhinolaryngology, head and neck diseases, 2016-02, Vol.133 (1), p.13-17

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objectives To describe the clinical, histological and therapeutic characteristics of a prospective multicenter series of 95 head and neck adenoid cystic carcinoma patients, and to determine any prognostic factors for disease-free survival. Patients and methods Ninety-five patients with adenoid cystic carcinoma were included in the Réseau d’Expertise Français Des Cancers ORL Rares (REFCOR, French Rare Head and Neck Cancer Expert Network) database between 2009 and 2012. The primary site was the salivary glands in 39 cases, sinus cavities (including hard palate) in 36 cases, pharynx-larynx-trachea in 14 cases, and lips and oral cavity in 4 cases. The tumor was stage I in 15% of cases, stage II in 23%, stage III in 26% and stage IV in 36%. Nine patients had cervical lymph node involvement and 5 had metastases at diagnosis. Fifty-six percent of patients were managed by surgery with postoperative radiation therapy. During follow-up, 3 patients died, 9 developed metastases and 12 showed recurrence or local progression. Results Mean follow-up was 18 months. On univariate analysis, disease-free survival correlated with T stage ( P = 0.05), N stage ( P = 0.003), resection margins ( P = 0.04), lymph node involvement on histology ( P = 0.01), and absence of chemotherapy ( P = 0.03). On multivariate analysis, disease-free survival correlated with T stage ( P = 0.01), N stage ( P = 0.09) and surgery ( P = 0.005). Conclusion The essential issue in adenoid cystic carcinoma is long-term control. The present results confirm that the reference attitude is radical surgical resection for optimal local control. Adjuvant radiation therapy did not emerge as a prognostic factor. This study also provides a starting-point for translational studies in pathology and genetics.