Details

Autor(en) / Beteiligte

• Cuzin, Lise
• Pugliese, Pascal
• Sauné, Karine
• Allavena, Clotilde
• Ghosn, Jade
• Cottalorda, Jacqueline
• Rodallec, Audrey
• Chaix, Marie Laure
• Fafi-Kremer, Samira
• Soulié, Cathia
• Ouka, Marlène
• Charpentier, Charlotte
• Bocket, Laurence
• Mirand, Audrey
• Guiguet, Marguerite

Titel

Levels of intracellular HIV-DNA in patients with suppressive antiretroviral therapy

Ist Teil von

• AIDS (London), 2015-08, Vol.29 (13), p.1665-1671

Ort / Verlag

England: Wolters Kluwer

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• The objective of this study is to study factors associated with HIV-DNA levels in chronically infected patients on long-term suppressive antiretroviral therapy (ART). A cross-sectional, multicentre study of patients receiving ART for more than 3 years, HIV-RNA less than 50 copies/ml for more than 2 years and CD4 cell count more than 350 cells/μl. Factors associated with low (<150) or high (>1000), compared with intermediate (150-1000 copies/10 PBMCs) levels of HIV-DNA were investigated using multinomial logistic regression. Five hundred and twenty-two patients who initiated ART during the chronic phase were included (71% male; median peak HIV-RNA: 4.88 log10 copies/ml, CD4 cell count nadir: 222 cells/μl). Median ART duration was 13 years [interquartile range (IQR) 7-17], viral suppression was 5.7 years (IQR 3.9-8.5) and 66% of the patients never experienced ART failure. Median HIV-DNA was 323 copies/10 PBMCs (IQR, 129-717) with low, intermediate and high levels observed in 28.3, 55.4 and 16.3%, respectively. In multivariable analysis, women were more likely to achieve a low level of HIV-DNA. Each additional year with suppressed HIV-RNA increased the likelihood of low level and decreased the likelihood of high level of HIV-DNA. Peak HIV-RNA higher than 5log10 was always associated with a decreased risk of low and an increased risk of high HIV-DNA. For patients with peak HIV-RNA lower than 5log10, past ART failure was associated with high level of HIV-DNA. Chronically HIV-infected patients with long-term suppressive ART can achieve low total HIV-DNA but one over six still presented HIV-DNA above 1000 copies/10 PBMCs despite long-term viral suppression.