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High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure
Ist Teil von
The New England journal of medicine, 2015-06, Vol.372 (23), p.2185-2196
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Patients with acute hypoxemic respiratory failure were assigned to standard oxygen therapy, high-flow oxygen therapy, or noninvasive ventilation. The intubation rate did not differ significantly among the groups, but 90-day mortality was lower in the high-flow–oxygen group.
Noninvasive positive-pressure ventilation (hereafter, noninvasive ventilation) reduces the need for endotracheal intubation and mortality among patients with acute exacerbations of chronic obstructive pulmonary disease
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–
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or severe cardiogenic pulmonary edema.
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The physiological effects of noninvasive ventilation include a decrease in the work of breathing and improvement in gas exchange. In patients with acute hypoxemic respiratory failure, the need for mechanical ventilation is associated with high mortality,
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but data on the overall effects of noninvasive ventilation with respect to the prevention of intubation and improvement in outcome are conflicting.
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–
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Previous studies have often included a heterogeneous population of patients with . . .