Details

Autor(en) / Beteiligte

• Costopoulos, Myrto
• Kim, Rathana
• Choquet, Sylvain
• Maloum, Karim
• Houillier, Caroline
• Algrin, Caroline
• Settegrana, Catherine
• Villemonteix, Juliette
• Brissard, Martine
• Quiney, Claire
• Bernard, Sophie
• Davi, Frederic
• Thieblemont, Catherine
• Hoang-Xuan, Khe
• Leblond, Veronique
• Merle-Beral, Helene
• Le Garff-Tavernier, Magali

Titel

Cerebrospinal fluid interleukin (IL)-10 and IL-10:IL-6 ratio as biomarkers for small B-cell lymphoproliferations with leptomeningeal dissemination

Ist Teil von

• Seminars in hematology, 2018-10, Vol.55 (4), p.179-181

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We here report for the first time that low levels of interleukin (IL)-10 do not exclude lymphomatous meningitis (LM) in B-cell lymphoproliferative disorders (CLPD). Unexpectedly, IL-10 levels and IL-10:IL-6 ratio in CLPD differed from the levels observed in diffuse large B-cell lymphoma (DLBCL). We report the usefulness of adding the IL-10:IL-6 ratio in order to potentially reveal more aggressive lymphomas: either a transformation or an association with another “hidden” lymphoma such as primary CNS lymphoma (PCNSL).