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Predicting and treating stress-Induced vulnerability to epilepsy and depression
Ist Teil von
Annals of neurology, 2015-07, Vol.78 (1), p.128-136
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley Blackwell Single Titles
Beschreibungen/Notizen
Accumulation of stressful events can render individuals susceptible to develop epilepsy and comorbidities. Whether such vulnerability can be predicted and reversed is not known. Here we show that social defeat, although not producing depression by itself, produced in 50% of rats reduced threshold for status epilepticus (SE), accelerated epileptogenesis, and once epilepsy was induced, depression‐like profile and cognitive deficits. Low serum brain‐derived neurotrophic factor (BDNF) levels measured before SE identified this vulnerable population. Treatment with a BDNF analog before SE prevented the occurrence of comorbidities. Thus, vulnerability to comorbidities after epilepsy onset due to unresolved past stressful events may be predicted and reversed. Ann Neurol 2015;78:128–136