Details

Autor(en) / Beteiligte

• Tabouret, Emeline
• Denicolai, Emilie
• Delfino, Christine
• Graillon, Thomas
• Boucard, Celine
• Nanni, Isabelle
• Padovani, Laetitia
• Figarella-Branger, Dominique
• Chinot, Olivier

Titel

Changes in PlGF and MET-HGF expressions in paired initial and recurrent glioblastoma

Ist Teil von

• Journal of neuro-oncology, 2016-12, Vol.130 (3), p.431-437

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Angiogenesis is one of the key features of glioblastoma (GB). However, the use of anti-angiogenic therapies directed against vascular endothelial growth factor (VEGF) is limited by primary or acquired resistance. MET/HGF and PlGF signaling are involved in potential alternative escape mechanisms to VEGF pathway. Our objective was to explore the potential changes of MET / HGF and PlGF expression, comparing initial diagnosis and recurrence after radiotherapy-temozolomide (RT/TMZ). Paired frozen tumors from both initial and recurrent surgery after radio-chemotherapy were available for 28 patients. RNA expressions of PlGF, MET , and HGF genes were analyzed by RT-qPCR. PlGF expression significantly decreased at recurrence ( p  = 0.021), and expression of MET showed a significant increase ( p  = 0.011) at recurrence. RNA expressions of MET and HGF significantly correlated both at baseline and recurrence (baseline: p  = 0.005; recurrence: p  = 0.019). Evolutive profile (increasing versus decreasing expression at recurrence) of MET was associated with PFS ( p  = 0.002) and OS ( p  = 0.022) at recurrence, while the evolutive profile of HGF was associated with PFS at relapse ( p  = 0.049). Recurrence of GB after chemo-radiation could be associated with a variation in PlGF and MET expression. These results contribute to suggest a modification of the GB angiogenic process between initial diagnosis and recurrence.