Lung cancer (Amsterdam, Netherlands), 2016-08, Vol.98, p.51-58
2016
Details
- Autor(en) / Beteiligte
- Titel
- Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages
- Ist Teil von
- Lung cancer (Amsterdam, Netherlands), 2016-08, Vol.98, p.51-58
- Ort / Verlag
- Ireland: Elsevier B.V
- Erscheinungsjahr
- 2016
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • PD-L1, tumor-infiltrating lymphocytes (TIL) were higher in SC than in NSCLC. • High levels of TIL constituted a factor of good prognosis. • PD-L1 expression distinguishes subpopulations within tumor-infiltrating lymphocytes (CD3+ or CD4+) with different prognosis. • This result could represent a justification for the use of PD-L1/PD-1 immunotherapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0169-5002eISSN: 1872-8332DOI: 10.1016/j.lungcan.2016.05.013Titel-ID: cdi_hal_primary_oai_HAL_hal_01320746v1
- Format
- –
- Schlagworte
- Adult, Aged, B7-H1 Antigen - genetics, B7-H1 Antigen - metabolism, Biomarkers, Tumor, Cancer, Female, Hematology, Oncology and Palliative Medicine, Humans, Kaplan-Meier Estimate, Life Sciences, Lung Neoplasms - immunology, Lung Neoplasms - metabolism, Lung Neoplasms - mortality, Lung Neoplasms - pathology, Lung sarcomatoid carcinoma, Lymphocytes, Tumor-Infiltrating - immunology, Lymphocytes, Tumor-Infiltrating - metabolism, Macrophages - immunology, Macrophages - metabolism, Macrophages - pathology, Male, Middle Aged, Mutation, Neoplasm Metastasis, Neoplasm Staging, Non-small-cell lung cancer, Odds Ratio, PD-L1, Prognosis, Pulmonary/Respiratory, Tumor-Infiltrating lymphocytes, Tumor-Infiltratingmacrophages