Details

Autor(en) / Beteiligte

• Turati, Federica
• Edefonti, Valeria
• Talamini, Renato
• Ferraroni, Monica
• Malvezzi, Matteo
• Bravi, Francesca
• Franceschi, Silvia
• Montella, Maurizio
• Polesel, Jerry
• Zucchetto, Antonella
• La Vecchia, Carlo
• Negri, Eva
• Decarli, Adriano

Titel

Family history of liver cancer and hepatocellular carcinoma

Ist Teil von

• Hepatology (Baltimore, Md.), 2012-05, Vol.55 (5), p.1416-1425

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Familial clustering of hepatocellular carcinoma (HCC) has been frequently reported in eastern Asiatic countries, where hepatitis B infection is common. Little is known about the relationship between family history of liver cancer and HCC in Western populations. We carried out a case‐control study in Italy, involving 229 HCC cases and 431 hospital controls. Data on family history were summarized through a binary indicator (yes/no) and a family history score (FHscore), considering selected family characteristics. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained from unconditional multiple logistic regression models, including terms for age, sex, study center, education, tobacco smoking, alcohol drinking, hepatitis B surface antigen, and/or anti–hepatitis C virus positivity. We also performed a meta‐analysis on family history of liver cancer and liver cancer updated to April 2011 using random‐effects models. After adjustment for chronic infection with hepatitis B/C viruses, family history of liver cancer was associated with HCC risk, when using both the binary indicator (OR, 2.38; 95% CI, 1.01‐5.58) and the FHscore, with increasing ORs for successive score categories. Compared to subjects without family history and no chronic infection with hepatitis B/C viruses, the OR for those exposed to both risk factors was 72.48 (95% CI, 21.92‐239.73). In the meta‐analysis, based on nine case‐control and four cohort studies, for a total of approximately 3,600 liver cancer cases, the pooled relative risk for family history of liver cancer was 2.50 (95% CI, 2.06‐3.03). Conclusion: A family history of liver cancer increases HCC risk, independently of hepatitis. The combination of family history of liver cancer and hepatitis B/C serum markers is associated with an over 70‐fold elevated HCC risk. (HEPATOLOGY 2011)