Details

Autor(en) / Beteiligte

• Si-Tahar, Mustapha
• Blanc, Fany
• Furio, Laetitia
• Chopy, Damien
• Balloy, Viviane
• Lafon, Monique
• Chignard, Michel
• Fiette, Laurence
• Langa, Francina
• Charneau, Pierre
• Pothlichet, Julien

Titel

Protective Role of LGP2 in Influenza Virus Pathogenesis

Ist Teil von

• The Journal of infectious diseases, 2014-07, Vol.210 (2), p.214-223

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2014

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Influenza A virus triggers a contagious respiratory disease that can cause considerable morbidity and mortality. Using an in vitro approach, we previously demonstrated that the pattern recognition receptor retinoic acidinducible gene I (RIG-I) plays a key role in influenza A virus-mediated immune response. However, the importance of RIG-I signaling in vivo has not been thoroughly examined, because of the lack of an appropriate mouse models. To circumvent this issue, we generated a new transgenic mouse overexpressing LGP2 (hereafter, "LGP2 TG mice"), a major regulator of the RIG-I signaling pathway. The time course of several parameters was compared in infected wild-type and LGP2 TG mice. We found that LGP2 TG mice displayed significantly reduced inflammatory mediators and a lower leukocyte infiltration into the bronchoalveolar airspace. More importantly, LGP2 TG mice had a significant survival advantage. Hence, our in vivo study reveals that LGP2 is a major downregulator of the influenza A virus-triggered detrimental inflammatory response.