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BibTeX
Impact of 60-GHz millimeter waves and corresponding heat effect on endoplasmic reticulum stress sensor gene expression
Bioelectromagnetics, 2014-09, Vol.35 (6), p.444-451
Le Quément, Catherine
Nicolaz, Christophe Nicolas
Habauzit, Denis
Zhadobov, Maxim
Sauleau, Ronan
Le Dréan, Yves
2014
Details
Autor(en) / Beteiligte
Le Quément, Catherine
Nicolaz, Christophe Nicolas
Habauzit, Denis
Zhadobov, Maxim
Sauleau, Ronan
Le Dréan, Yves
Titel
Impact of 60-GHz millimeter waves and corresponding heat effect on endoplasmic reticulum stress sensor gene expression
Ist Teil von
Bioelectromagnetics, 2014-09, Vol.35 (6), p.444-451
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Emerging high data rate wireless communication systems, currently under development, will operate at millimeter waves (MMW) and specifically in the 60 GHz band for broadband short‐range communications. The aim of this study was to investigate potential effects of MMW radiation on the cellular endoplasmic reticulum (ER) stress. Human skin cell lines were exposed at 60.4 GHz, with incident power densities (IPD) ranging between 1 and 20 mW/cm2. The upper IPD limits correspond to the ICNIRP local exposure limit for the general public. The expression of ER‐stress sensors, namely BIP and ORP150, was then examined by real‐time RT‐PCR. Our experimental data demonstrated that MMW radiations do not change BIP or ORP150 mRNA basal levels, whatever the cell line, the exposure duration or the IPD level. Co‐exposure to the well‐known ER‐stress inducer thapsigargin (TG) and MMW were then assessed. Our results show that MMW exposure at 20 mW/cm2 inhibits TG‐induced BIP and ORP150 over expression. Experimental controls showed that this inhibition is linked to the thermal effect resulting from the MMW exposure. Bioelectromagnetics. 35:444–451, 2014. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0197-8462
eISSN: 1521-186X
DOI: 10.1002/bem.21864
Titel-ID: cdi_hal_primary_oai_HAL_hal_01063910v1
Format
–
Schlagworte
60-GHz band
,
biological effects
,
BIP
,
Cell Line
,
Electromagnetic Radiation
,
Endoplasmic Reticulum Stress - drug effects
,
Endoplasmic Reticulum Stress - genetics
,
Endoplasmic Reticulum Stress - physiology
,
Endoplasmic Reticulum Stress - radiation effects
,
Enzyme Inhibitors - pharmacology
,
Gene Expression - drug effects
,
Gene Expression - physiology
,
Gene Expression - radiation effects
,
Hot Temperature
,
HSP70 Heat-Shock Proteins - metabolism
,
Humans
,
keratinocytes
,
Life Sciences
,
millimeter waves
,
ORP-150
,
Real-Time Polymerase Chain Reaction
,
RNA, Messenger - metabolism
,
Skin - drug effects
,
Skin - radiation effects
,
Skin Physiological Phenomena - drug effects
,
Skin Physiological Phenomena - genetics
,
Skin Physiological Phenomena - radiation effects
,
Thapsigargin - pharmacology
,
Time Factors
,
Wireless Technology
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