Behavioural brain research, 2010-09, Vol.212 (1), p.56-63
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Predicting sensorimotor and memory deficits after neonatal ischemic stroke with reperfusion in the rat
- Ist Teil von
- Behavioural brain research, 2010-09, Vol.212 (1), p.56-63
- Ort / Verlag
- Shannon: Elsevier B.V
- Erscheinungsjahr
- 2010
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Among experimental models of perinatal ischemic stroke, Renolleau's model mimics selected types of stroke at birth, including ischemia and reperfusion. However, its behavioural consequences on development have been poorly described. Here, ischemia-reperfusion was performed in 7-day-old Wistar rats. Between the ages of 9 and 40 days, sensorimotor and memory functions were assessed. The infarcted area was analysed by immunohistochemistry at 40 days of age. The remaining lesion was in the parietal cortex, in the form of a cone-shaped area. This area contained glial cells but neither neurons nor macrophages. Transient focal neonatal ischemia led to sensorimotor alterations in early adulthood, such as postural asymmetry, motor coordination and somatosensory deficits, and hyperactivity, as well as cognitive impairments, such as spatial reference memory deficits. Based on these results, we propose here a selection of behavioural tests that should constitute meaningful tools for assessing sensory and cognitive functions after experimental neonatal ischemic stroke.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-4328eISSN: 1872-7549DOI: 10.1016/j.bbr.2010.03.043Titel-ID: cdi_hal_primary_oai_HAL_hal_00863083v1
- Format
- –
- Schlagworte
- Age Factors, Analysis of Variance, Animals, Animals, Newborn, Antigens - metabolism, Avoidance Learning - physiology, Behavioral psychophysiology, Biological and medical sciences, Brain - metabolism, Brain - pathology, Cognitive science, Development, Disease Models, Animal, Double-Blind Method, Ectodysplasins - metabolism, Exploratory Behavior - physiology, Female, Fundamental and applied biological sciences. Psychology, Gait Disorders, Neurologic - diagnosis, Gait Disorders, Neurologic - etiology, Glial Fibrillary Acidic Protein - metabolism, Gliosis, Ischemic Attack, Transient - complications, Male, Maze Learning - physiology, Medical sciences, Memory, Memory Disorders - diagnosis, Memory Disorders - etiology, Motor Activity - physiology, Neurology, Neuroscience, Perinatal ischemia, Phosphopyruvate Hydratase - metabolism, Predictive Value of Tests, Pregnancy, Proteoglycans - metabolism, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Rats, Rats, Wistar, Reflex - physiology, Reperfusion, Sensorimotor functions, Statistics as Topic, Vascular diseases and vascular malformations of the nervous system