Details

Autor(en) / Beteiligte

• Noel, Nicolas, MD, MSc
• Mahlaoui, Nizar, MD, MSc, MPH
• Blanche, Stéphane, MD, PhD
• Suarez, Felipe, MD, PhD
• Coignard-Biehler, Hélène, MD
• Durieu, Isabelle, MD, PhD
• Godeberge, Philippe, MD
• Sokol, Harry, MD, PhD
• Catherinot, Emilie, MD, PhD
• Poiree, Sylvain, MD
• Chapdelaine, Hugo, MD
• Dunogue, Bertrand, MD, MSc
• Bodemer, Christine, MD, PhD
• Lecuit, Marc, MD, PhD
• Fischer, Alain, MD, PhD
• Lortholary, Olivier, MD, PhD
• Hermine, Olivier, MD, PhD

Titel

Efficacy and safety of thalidomide in patients with inflammatory manifestations of chronic granulomatous disease: A retrospective case series

Ist Teil von

• Journal of allergy and clinical immunology, 2013-10, Vol.132 (4), p.997-1000.e4

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2013

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Immunosuppressive agents (corticosteroids and azathioprine) are associated with significant adverse effects, mostly infections. [...]in a series of 5 patients treated with anti-TNF- agents,3 infections were more frequent, and 2 deaths occurred despite effectiveness in severe colitis, thus raising concerns regarding their safety in such patients. Because patients 3 and 6 experienced improvement in their pseudomass lesions after 6 and 12 months (see Figs E2 and E3), patients 4 and 5 did not show any improvement in their interstitial pattern, fibrotic pattern, or both (see Fig E4).