Details

Autor(en) / Beteiligte

• Silvy, M.
• Chapel‐Fernandes, S.
• Beley, S.
• Durousseau, C.
• Granier, T.
• Zappitelli, J. P.
• Bailly, P.
• Chiaroni, J.

Titel

Molecular characterization of a new D‐ ‐ haplotype in a Comorian man

Ist Teil von

• Vox sanguinis, 2012-11, Vol.103 (4), p.352-355

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• The D‐ ‐ phenotype is a genetic variant of the Rh blood group system. It expresses D antigen but lacks C, c, E and e antigens. In D‐ ‐ phenotype, the RHCE coding region is extensively modified by RHD sequence replacement, nucleotide deletion or splice‐site changes. This article reports the identification of a new D‐ ‐ haplotype in a Comorian man. It exhibits a hybrid gene in which RHCE gene exons 3–8 have been replaced by RHD sequences on the RHCE * C allele background. This allele is associated with no expression of c/C and e/E antigens and overexpression of RhD antigen.