Journal of medical microbiology, 2011-05, Vol.60 (5), p.563-573
2011
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- Autor(en) / Beteiligte
- Titel
- Bacterial hypermutation: clinical implications
- Ist Teil von
- Journal of medical microbiology, 2011-05, Vol.60 (5), p.563-573
- Ort / Verlag
- Reading: Society for General Microbiology
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Heritable hypermutation in bacteria is mainly due to alterations in the methyl-directed mismatch repair (MMR) system. MMR-deficient strains have been described from several bacterial species, and all of the strains exhibit increased mutation frequency and recombination, which are important mechanisms for acquired drug resistance in bacteria. Antibiotics select for drug-resistant strains and refine resistance determinants on plasmids, thus stimulating DNA recombination via the MMR system. Antibiotics can also act as indirect promoters of antibiotic resistance by inducing the SOS system and certain error-prone DNA polymerases. These alterations have clinical consequences in that efficacious treatment of bacterial infections requires high doses of antibiotics and/or a combination of different classes of antimicrobial agents. There are currently few new drugs with low endogenous resistance potential, and the development of such drugs merits further research.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2615eISSN: 1473-5644DOI: 10.1099/jmm.0.024083-0Titel-ID: cdi_hal_primary_oai_HAL_hal_00752580v1
- Format
- –
- Schlagworte
- Antibiotic resistance, Antibiotics, Antimicrobial agents, Bacteria, Bacteria - drug effects, Bacteria - genetics, Bacteria - metabolism, Bacteria - pathogenicity, Bacterial Infections, Bacterial Infections - drug therapy, Bacterial Infections - microbiology, Bacteriology, Biological and medical sciences, Cystic Fibrosis, Cystic Fibrosis - microbiology, DNA Mismatch Repair, DNA Mismatch Repair - genetics, DNA-directed DNA polymerase, Drug development, Drug resistance, Drug Resistance, Bacterial, Drug Resistance, Bacterial - genetics, Foodborne Diseases, Foodborne Diseases - microbiology, Fundamental and applied biological sciences. Psychology, Genes, Bacterial, Humans, Infection, Infectious diseases, Interspersed Repetitive Sequences, Life Sciences, Medical sciences, Microbiology, Microbiology and Parasitology, Miscellaneous, mismatch repair, Mutation, Phenotype, Plasmids, Promoters, Prophages, Prophages - genetics, Recombination, Recombination, Genetic, SOS Response (Genetics), SOS Response, Genetics - genetics, Urinary Tract Infections, Urinary Tract Infections - microbiology, Virulence, Virulence - genetics