Details

Autor(en) / Beteiligte

• Viguier, M.
• Pagès, C.
• Aubin, F.
• Delaporte, E.
• Descamps, V.
• Lok, C.
• Beylot-Barry, M.
• Séneschal, J.
• Dubertret, L.
• Morand, J.-J.
• Dréno, B.
• Bachelez, H.

Titel

Efficacy and safety of biologics in erythrodermic psoriasis: a multicentre, retrospective study

Ist Teil von

• British journal of dermatology (1951), 2012-08, Vol.167 (2), p.417-423

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2012

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Summary Background  Even though efficacy of biologics has been extensively studied in psoriasis vulgaris, studies in erythrodermic psoriasis, the most severe form of the disease, have been scarcely reported. Objectives  To address the efficacy and safety of biologics in patients with erythrodermic psoriasis. Methods  A multicentre national retrospective study was performed using the French Psoriasis Group network. Patients showing psoriasis involving at least 90% of body surface area (BSA), and in whom severity of the disease had been evaluated before and after 3 and/or 6 months of treatment with biologics, were enrolled in the study. Results were expressed using intention‐to‐treat analysis. Results  We included 28 patients, representing 42 flares of erythrodermic psoriasis treated with infliximab (n = 24), adalimumab (n = 7), etanercept (n = 6), ustekinumab (n = 3) or efalizumab (n = 2). A 75% improvement of BSA or Psoriais Area and Severity Index 12–14 weeks after treatment onset was reached in 48% of flares treated with infliximab, in 50% of those treated with adalimumab and in 40% of those treated with etanercept. Twelve serious adverse events, consisting of bacterial infection in seven of them, were observed. Biological treatment was discontinued for safety concern in 19% of cases. A given biologic was administered for up to 48 weeks in 34% of flares. Conclusions  Biologics show overall good short‐term efficacy, but treatment switch due to lack of efficacy or side‐effects is frequently observed on a longer term, with only one‐third of patients still receiving the same drug after 1 year. The most significant safety concern consists of severe infections.