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Transferrin overexpression alters testicular function in aged mice
Molecular reproduction and development, 2007-02, Vol.74 (2), p.197-206
Lécureuil, C.
Staub, C.
Fouchécourt, S.
Maurel, M.C.
Fontaine, I.
Martinat, N.
Gauthier, C.
Daudignon, A.
Delaleu, B.
Sow, A.
Jégou, B.
Guillou, F.
2007
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Lécureuil, C.
Staub, C.
Fouchécourt, S.
Maurel, M.C.
Fontaine, I.
Martinat, N.
Gauthier, C.
Daudignon, A.
Delaleu, B.
Sow, A.
Jégou, B.
Guillou, F.
Titel
Transferrin overexpression alters testicular function in aged mice
Ist Teil von
Molecular reproduction and development, 2007-02, Vol.74 (2), p.197-206
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Many studies have shown a correlation between transferrin (Tf) concentration and sperm yield in several mammalian species. We have used transgenic mice expressing human Tf (hTf) to investigate if overexpression of Tf increases the efficiency of mouse spermatogenesis. We demonstrated that a 36% increase of Tf does not ameliorate the efficiency of mouse spermatogenesis but on the contrary resulted in a 36% decrease of testis sperm reserves. Tf overexpression had no effect on testicular determination and development, however testicular function of these transgenic mice was affected in an age‐dependent manner. At 16 months of age, testicular and epididymal weights were significantly reduced. While spermatogenesis was qualitatively normal, testicular functions were perturbed. In fact, testosterone rate after human chorionic gonadotropin (hCG) stimulation was lower in Tf overexpressing mice. Intratesticular concentration of estradiol‐17β was increased and fluid accumulation after ligation of rete testis was more abundant in these transgenic mice. Surprisingly, we found that endogenous Tf levels were also increased in Tf overexpressing mice and we demonstrated for the first time that Tf may serve to upregulate its own expression in testis. Collectively, our data show that Tf overexpression has negative effects on testicular function and that Tf levels require strict regulation in the testis. Mol. Reprod. Dev. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1040-452X
eISSN: 1098-2795
DOI: 10.1002/mrd.20523
Titel-ID: cdi_hal_primary_oai_HAL_hal_00686372v1
Format
–
Schlagworte
Animals
,
Biological and medical sciences
,
Crosses, Genetic
,
Female
,
Follicle Stimulating Hormone
,
Follicle Stimulating Hormone - secretion
,
Fundamental and applied biological sciences. Psychology
,
Gene Expression Regulation
,
Gene Expression Regulation, Developmental
,
Hormone metabolism and regulation
,
Humans
,
Life Sciences
,
Luteinizing Hormone
,
Luteinizing Hormone - secretion
,
Male
,
male sexual function
,
Mammalian male genital system
,
Mice
,
Mice, Inbred C57BL
,
Mice, Inbred Strains
,
Pituitary Gland
,
Pituitary Gland - secretion
,
Reproduction
,
Reproduction - physiology
,
Reproductive Biology
,
Sertoli cells
,
Spermatogenesis
,
Spermatogenesis - physiology
,
Testis
,
Testis - drug effects
,
Testis - growth & development
,
Testis - physiology
,
Testosterone
,
Testosterone - metabolism
,
Transferrin
,
Transferrin - genetics
,
Transferrin - pharmacology
,
Transferrin - physiology
,
Vertebrates: reproduction
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