Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2291-2296
2008
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Details
- Autor(en) / Beteiligte
- Titel
- β-Homo-amino Acid Scan of Angiotensin IV
- Ist Teil von
- Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2291-2296
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2008
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Angiotensin IV, a metabolite of angiotensin II, inhibits the enzyme insulin regulated aminopeptidase or IRAP and also, although with lower potency, aminopeptidase-N (AP-N). When both β2-homo amino acid- and β3-homo amino acid substitutions were used, allowed the identification of H-(R)β2hVal-Tyr-Ile-His-Pro-β3hPhe-OH as a potent and stable Ang IV analog with high selectivity for IRAP versus AP-N and the AT1 receptor.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623eISSN: 1520-4804DOI: 10.1021/jm701490gTitel-ID: cdi_hal_primary_oai_HAL_hal_00677465v1
- Format
- –
- Schlagworte
- Amino Acid Substitution, Amino Acids - chemistry, Aminopeptidases - antagonists & inhibitors, Angiotensin II - analogs & derivatives, Angiotensin II - chemical synthesis, Angiotensin II - chemistry, Angiotensin II - pharmacology, Animals, Binding Sites, Biological and medical sciences, CD13 Antigens - antagonists & inhibitors, Cell Line, Cell Membrane - drug effects, Chemical Sciences, CHO Cells, Cricetinae, Cricetulus, Dose-Response Relationship, Drug, Enzyme Activation - drug effects, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - pharmacology, Humans, Medical sciences, Miscellaneous, Molecular Structure, Neuropharmacology, Neurotransmitters. Neurotransmission. Receptors, Organic chemistry, Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems, Pharmacology. Drug treatments, Receptor, Angiotensin, Type 1 - drug effects, Structure-Activity Relationship