Phytotherapy research, 2011-02, Vol.25 (2), p.221-227
2011
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- Autor(en) / Beteiligte
- Titel
- effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes
- Ist Teil von
- Phytotherapy research, 2011-02, Vol.25 (2), p.221-227
- Ort / Verlag
- Chichester, UK: John Wiley & Sons, Ltd
- Erscheinungsjahr
- 2011
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The main bioactive compounds of Trigonella foenum graecum L. (fenugreek) seeds are protodioscin, trigoneoside, diosgenin and yamogenin, which have anticarcinogenic potency through inhibition of cell proliferation and inhibition of prostaglandin synthesis. The effect of fenugreek on ALOX and COX genes was examined in AKR/J H-2k mice exposed to dimethylbenz[α]anthracene (DMBA), a potent carcinogen. The expression pattern of these genes was determined by detecting the mRNA expression in various tissues (the lungs, liver, spleen and the kidneys) in four groups of mice. Two groups were fed with normal and two of them with fenugreek containing nutriment. Each group divided into DMBA treated and control groups. Mice were autopsied on day 7 after DMBA treatment for mRNA isolation. Fenugreek consumption itself did not change gene expression compared with the control group. DMBA could increase the expression of ALOX12, ALOX15, ALOX5 genes mainly in all organs. Fenugreek consumption was generally protective in each organ in a different manner. DMBA treatment increased COX2 gene expression, but fenugreek was protective in all tissues examined. In COX1 gene, the fenugreek diet could suppress the expression, except for spleen, independently from carcinogen exposure. Therefore by inhibiting the arachidonic acid metabolism fenugreek may prevent tumorigenesis. Copyright © 2010 John Wiley & Sons, Ltd.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0951-418X, 1099-1573eISSN: 1099-1573DOI: 10.1002/ptr.3231Titel-ID: cdi_hal_primary_oai_HAL_hal_00599825v1
- Format
- –
- Schlagworte
- 9,10-Dimethyl-1,2-benzanthracene, 9,10-Dimethyl-1,2-benzanthracene - toxicity, Animals, Arachidonate Lipoxygenases - drug effects, Arachidonate Lipoxygenases - metabolism, Arachidonic acid, Arachidonic Acid - metabolism, Biological and medical sciences, Carcinogens, Carcinogens - toxicity, Cell proliferation, chemoprevention, cyclooxygenase, Cyclooxygenase 1 - drug effects, Cyclooxygenase 1 - metabolism, Cyclooxygenase-1, Cyclooxygenase-2, Diets, Enzymes, Female, fenugreek, Gene expression, Gene Expression Regulation - drug effects, General pharmacology, Histocompatibility antigen H-2, Kidney, Kidney - drug effects, Kidney - enzymology, lipoxygenase, Liver, Liver - drug effects, Liver - enzymology, Lung, Lung - drug effects, Lung - enzymology, Medical sciences, Membrane Proteins - drug effects, Membrane Proteins - metabolism, Metabolism, Mice, Mice, Inbred AKR, Pharmacognosy. Homeopathy. Health food, Pharmacology. Drug treatments, Phytotherapy, Plant Extracts - pharmacology, Prostaglandins, Spleen, Spleen - drug effects, Spleen - enzymology, Trigonella - chemistry, Trigonella foenum graecum, Tumorigenesis