Molecular and cellular endocrinology, 2008-05, Vol.286 (1), p.75-87
2008
Details
- Autor(en) / Beteiligte
- Titel
- Somatostatinergic systems in brain: Networks and functions
- Ist Teil von
- Molecular and cellular endocrinology, 2008-05, Vol.286 (1), p.75-87
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-coupled receptor family. Recent advances in the neuroanatomy of somatostatin neurons and cellular distribution of sst receptors shed light on their functional roles in the neuronal network. Beside their initially described neuroendocrine role, somatostatin systems subserve neuromodulatory roles in the brain, influencing motor activity, sleep, sensory processes and cognitive functions, and are altered in brain diseases like affective disorders, epilepsia and Alzheimer's disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0303-7207eISSN: 1872-8057DOI: 10.1016/j.mce.2007.09.007Titel-ID: cdi_hal_primary_oai_HAL_hal_00531952v1
- Format
- –
- Schlagworte
- Alzheimer Disease - metabolism, Animals, Brain - anatomy & histology, Brain - metabolism, Brain - physiology, Central nervous system, Epilepsy - metabolism, Humans, Interneurons, Life Sciences, Mood Disorders - metabolism, Neurons and Cognition, Neurotransmitter Agents - physiology, Protein Multimerization, Receptors, Receptors, G-Protein-Coupled - physiology, Receptors, Somatostatin - agonists, Receptors, Somatostatin - physiology, Signal Transduction, Somatostatin, Somatostatin - physiology, Spinal Cord - metabolism, Sst