Details

Autor(en) / Beteiligte

• Gayon, Eric
• Debleds, Olivier
• Nicouleau, Marie
• Lamaty, Frédéric
• van Der Lee, Arie
• Vrancken, Emmanuel
• Campagne, Jean-Marc

Titel

Highly Diastereoselective Baldwin Rearrangement of Isoxazolines into Acylaziridines

Ist Teil von

• Journal of organic chemistry, 2010-08, p.6050-6053

Ort / Verlag

American Chemical Society

Erscheinungsjahr

2010

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An atom-economical and practical synthesis of cis-N- benzenesulfonamide acylaziridines through the Baldwin rearrangement of various N-benzenesulfonamide isoxa- zolines has been reported. A detailed experimental study revealed the beneficial effect of microwaves and pointed out the crucial role of the temperature in the reaction course. Moderate to good yields and excellent cis stereo- selectivities were achieved for 13 examples.