Chemistry : a European journal, 2010-05, Vol.16 (20), p.5863-5867
2010
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Details
- Autor(en) / Beteiligte
- Titel
- Palladium-Catalyzed Domino Process to Spirooxindoles: Ligand Effect on Aminopalladation versus Carbopalladation
- Ist Teil von
- Chemistry : a European journal, 2010-05, Vol.16 (20), p.5863-5867
- Ort / Verlag
- Weinheim: WILEY-VCH Verlag
- Erscheinungsjahr
- 2010
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Double intra, from linear to spiro: A Pd‐catalyzed domino sequence involving an intramolecular aminopalladation followed by arylation that convert linear anilides 1 into the functionalized spiropyrrolidine‐3,3′‐oxindoles 2 in good to excellent yields is presented. The use of 2‐di‐tert‐butylphosphino‐2′‐methylbiphenyl as a ligand determines the success of the domino process. A trans‐aminopalladation mechanism seems to account for the observed diastereoselectivity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0947-6539eISSN: 1521-3765DOI: 10.1002/chem.201000312Titel-ID: cdi_hal_primary_oai_HAL_hal_00511899v1
- Format
- –
- Schlagworte
- aminopalladation, Anilides, Anilides - chemistry, carbopalladation, Catalysis, Cellular Biology, Chemistry, Cyclization, domino reactions, Heterocyclic Compounds, Heterocyclic Compounds - chemistry, Indoles, Indoles - chemistry, Life Sciences, Ligands, oxindoles, Palladium, Palladium - chemistry, Spiro Compounds, Spiro Compounds - chemistry, Structure-Activity Relationship