Details

Autor(en) / Beteiligte

• Harrison, Luke R.E.
• Ottley, Christopher J.
• Pearson, D. Graham
• Griffin, Roger J.
• Wedge, Stephen R.
• Dolan, M. Eileen
• Newell, David R.
• Tilby, Michael J.

Titel

The kinase inhibitor cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2

Ist Teil von

• Biochemical pharmacology, 2009-04, Vol.77 (10)

Ort / Verlag

Elsevier

Erscheinungsjahr

2009

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• -Cyclohexylmethylguanine (NU2058) was developed as an inhibitor of CDK2 and was previously shown to potentiate cisplatin cytotoxicity . The aim of this study was to investigate the mechanism of cisplatin potentiation by NU2058.