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GC-biased gene conversion promotes the fixation of deleterious amino acid changes in primates
Ist Teil von
Trends in genetics, 2009-01, Vol.25 (1), p.1-5
Ort / Verlag
Amsterdam: Elsevier Ltd
Erscheinungsjahr
2009
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
GC-biased gene conversion (gBGC) is a recently discovered, recombination-associated segregation distortion, which influences GC-content dynamics in the mammalian genome. We scanned the primate proteome for examples of exon-specific, lineage-specific accelerated amino acid evolution. Here, we show that such episodes are frequently accompanied by an increase in GC-content, which extends to synonymous and intronic positions. This demonstrates that gBGC has substantially (negatively) impacted the evolutionary trajectory of human proteins by promoting the fixation of deleterious AT→GC mutations.