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Developmental switch from LTD to LTP in low frequency-induced plasticity
Hippocampus, 2006-01, Vol.16 (11), p.981-989
2006

Details

Autor(en) / Beteiligte
Titel
Developmental switch from LTD to LTP in low frequency-induced plasticity
Ist Teil von
  • Hippocampus, 2006-01, Vol.16 (11), p.981-989
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2006
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
  • The stimulation of the Schaffer collateral/commissural fibers at low frequency (1 Hz) for 3–5 min can trigger a slow‐onset form of low‐frequency stimulation (LFS)‐long‐term potentiation (LTP) (LFS‐LTP) in the CA1 area of the adult rat hippocampus. Here we have examined the developmental profile of this plasticity. In 9–15 day‐old rats, the application of 1 Hz for 5 min induced long‐term depression (LFS‐LTD). In 17–21 day‐old rats, 1 Hz stimulation had no effect when applied for 5 min but mediated LTD when stimulus duration was increased to 15 min. Over 25 day‐old, 1 Hz stimulation mediated LFS‐LTP. LFS‐LTD was dependent on both N‐methyl‐D‐aspartate (NMDA) and mGlu5 receptor activation. Antagonists of mGlu1α and cannabinoid type 1 receptor were ineffective to block LTD induction. LFS‐LTD was not associated with a change in paired‐pulse facilitation ratio, suggesting a postsynaptic locus of expression of this plasticity. Next, we examined whether LFS‐LTD was related to ‘chemical’ LTDs obtained by the direct stimulation of mGlu5 and NMDA receptors. The saturation of LFS‐LTD completely occluded NMDA‐ and (RS)‐2‐Chloro‐5‐hydroxyphenylglycine (CHPG)‐induced LTD. CHPG‐LTD and NMDA‐LTD occluded each other. In addition, we observed that NMDA‐LTD was dependent on mGlu5 receptor activation in 9–12 day old rats while it was not in animals older than 15 day‐old. Therefore we postulate that during LFS application, NMDA and mGlu5 receptor could interact to trigger LTD. Low‐frequency‐mediated synaptic plasticity is subject to a developmental switch from NMDA‐ and mGlu5 receptor‐dependent LTD to mGlu5 receptor‐dependent LTP with a transient period (17–21 day‐old) during which LFS is ineffective. © 2006 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1050-9631
eISSN: 1098-1063
DOI: 10.1002/hipo.20228
Titel-ID: cdi_hal_primary_oai_HAL_hal_00397596v1
Format
–
Schlagworte
Age Factors, Animals, Animals, Newborn, Benzoxazines, Calcium Channel Blockers, Calcium Channel Blockers - pharmacology, CHPG, Dose-Response Relationship, Radiation, Drug Interactions, Electric Stimulation, Electric Stimulation - methods, Excitatory Amino Acid Agonists, Excitatory Amino Acid Agonists - pharmacology, Excitatory Amino Acid Antagonists, Excitatory Amino Acid Antagonists - pharmacology, Female, Glycine, Glycine - analogs & derivatives, Glycine - pharmacology, Hippocampus, Hippocampus - growth & development, Hippocampus - physiology, Hippocampus - radiation effects, In Vitro Techniques, Life Sciences, Long-Term Potentiation, Long-Term Potentiation - drug effects, Long-Term Potentiation - physiology, Long-Term Potentiation - radiation effects, Long-Term Synaptic Depression, Long-Term Synaptic Depression - drug effects, Long-Term Synaptic Depression - physiology, Long-Term Synaptic Depression - radiation effects, Male, mGlu5, microelectrode array, Morpholines, Morpholines - pharmacology, MPEP, N-Methylaspartate, N-Methylaspartate - pharmacology, Naphthalenes, Naphthalenes - pharmacology, Neurons and Cognition, NMDA, Phenylacetates, Phenylacetates - pharmacology, Piperidines, Piperidines - pharmacology, Pyrazoles, Pyrazoles - pharmacology, Rats

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