Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.31-32
2008
Details
- Autor(en) / Beteiligte
- Titel
- PNA-peptide conjugates as intracellular gene control agents
- Ist Teil von
- Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.31-32
- Ort / Verlag
- England: Oxford University Press
- Erscheinungsjahr
- 2008
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Abstract Serum-stabilized PNA-internalization peptides (Pip) conjugated to PNA complementary to the 705 aberrant β-globin splice site are able to correct splicing and increase luciferase production in Hela pLuc705 cells with sub μM EC50 in the absence of a transfection agent. Inhibition of microRNA-122 in liver cells is achieved by treatment with complementary PNA containing just a few attached Lys residues, again without need of a transfection agent.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0261-3166eISSN: 1746-8272DOI: 10.1093/nass/nrn016Titel-ID: cdi_hal_primary_oai_HAL_hal_00374442v1
- Format
- –
- Schlagworte
- Animals, beta-Globins - genetics, Biochemistry, Molecular Biology, HeLa Cells, Humans, Life Sciences, Luciferases, Firefly - biosynthesis, Mice, MicroRNAs - antagonists & inhibitors, MicroRNAs - metabolism, Muscular Dystrophy, Duchenne - genetics, Peptide Nucleic Acids - chemistry, RNA Splicing