pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-γ production
2009
Details
- Autor(en) / Beteiligte
- Titel
- pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-γ production
- Ist Teil von
- European journal of immunology, 2009-04, Vol.39 (4), p.1046-1055
- Ort / Verlag
- Weinheim: Wiley-VCH Verlag
- Erscheinungsjahr
- 2009
- Link zum Volltext
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- IL-33 has recently been identified as a cytokine endowed with pro-Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL-4 producers. Here, we report a two-fold increase of iNKT-cell counts in spleen and liver after a 7-day treatment of mice with IL-33, which results from a direct effect, given that purified iNKT cells express the T1/ST2 receptor constitutively and respond to IL-33 by in vitro expansion and functional activation. Conversely to the expected pro-Th2 effect, IL-33 induced a preferential increase in IFN-γ rather than IL-4 production upon TCR engagement that depended on endogenous IL-12. Moreover, in combination with the pro-inflammatory cytokine IL-12, IL-33 enhanced IFN-γ production by both iNKT and NK cells. Taken together these data support the conclusion that IL-33 can contribute as a co-stimulatory factor to innate cellular immune responses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-2980eISSN: 1521-4141DOI: 10.1002/eji.200838575Titel-ID: cdi_hal_primary_oai_HAL_hal_00356489v1
- Format
- –
- Schlagworte
- Animals, Cytokines, Female, Humans, Inflammation, Interferon-gamma - agonists, Interferon-gamma - immunology, Interferon-gamma - metabolism, Interleukin-12 - immunology, Interleukin-12 - metabolism, Interleukin-33, Interleukin-4 - agonists, Interleukin-4 - immunology, Interleukin-4 - metabolism, Interleukins - immunology, Interleukins - pharmacology, Killer Cells, Natural - drug effects, Killer Cells, Natural - immunology, Killer Cells, Natural - metabolism, Liver - drug effects, Liver - immunology, Liver - metabolism, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Natural killer cells, Natural killer T cells, Natural Killer T-Cells - drug effects, Natural Killer T-Cells - immunology, Natural Killer T-Cells - metabolism, Spleen - drug effects, Spleen - immunology, Spleen - metabolism, Th1/Th2 cells, Th2 Cells - drug effects, Th2 Cells - immunology, Th2 Cells - metabolism