Details

Autor(en) / Beteiligte

• Villapol, Sonia
• Gelot, Antoinette
• Renolleau, Sylvain
• Charriaut-Marlangue, Christiane

Titel

Astrocyte Responses after Neonatal Ischemia: The Yin and the Yang

Ist Teil von

• The Neuroscientist (Baltimore, Md.), 2008-08, Vol.14 (4), p.339-344

Ort / Verlag

Los Angeles, CA: SAGE Publications

Erscheinungsjahr

2008

Quelle

MEDLINE

Beschreibungen/Notizen

• Neonatal encephalopathy is a major predictor of neurodevelopmental disability in term infants and occurs in 1 to 6 of every 1000 live term births. Despite improvements in perinatal practice during the past several decades, the incidence of cerebral palsy attributed to neonatal asphyxia remained essentially unchanged, primarily because management strategies were supportive and not targeted toward the processes of ongoing injury. Traditionally, experimental research in vivo focused on neurons, and more recently, oligodendrocytes whereas astrocytes have been more or less neglected. This review aims at dissecting possible protective as well as destructive roles of astrocytes in the immature ischemic brain to stimulate further research into this unexplored aspect of brain pathophysiology. NEUROSCIENTIST 14(4):339ndash;344, 2008. DOI: 10.1177/1073858408316003